•  Top, © Copyright 2021  •  Dove Press Ltd   Various pruritic lesions treated with the 308 nm excimer laser have also demonstrated positive results. This is a discussion that should be had with patients and clinicians before treatment. 2006;22:181–183. The United States Federal Drug Administration approved the XTRAC (Excimer) laser for psoriasis therapy in 2009. Finally, use of clobetasol spray and ointment in conjunction with the excimer laser resulted in a safer side effect profile, as well as improved clearance of lesions in the long term.30. Nestle F, Kaplan D, Barker J. Psoriasis. •  software development by maffey.com Dermatol Surg. Quintessence Int. Rogalski C, Grunewald S, Schetschorke M, Bodendorf MO, Kauer F, Simon JC, Paasch U. 2012 Apr;66(4):664-72. doi: 10.1016/j.jaad.2011.07.011. Epub 2011 Oct 14. Few adverse reactions have been reported, and they are consistent with adverse reactions associated with other forms of phototherapy including erythema, blistering, hyperpigmentation, and hypopigmentation (Figure 3). From submission to first editorial decision. Volume 2016:6 Pages 165—173, Editor who approved publication: This allowed researchers to achieve greater improvements in PASI score in a faster period of time. 2014;5:8–12. Dermatol Surg. Objective: To prospectively evaluate the effect of the excimer laser on plaque psoriasis using an optimal therapeutic dose (OTD) protocol. However, if patients are more concerned with side effects of blistering, erythema, and tenderness, then the MED or Induration protocols may be more advantageous. The combined analysis of these studies showed that $64 of patients with palmoplantar pustular psoriasis experienced an improvement of at least 70% at the end of treatment. Nonetheless, excimer lasers have been an effective therapy regardless of method utilized in various protocols. This aspect potentially reduces the patient’s skin cancer risk and can feasibly improve patient compliance.1 Furthermore, the excimer laser has the ability to target difficult to reach areas and administer site-specific dosing.16 Also, it can operate with the ability to change the energy level (in millijoules) delivered during treatment. Excimer lasers aim a high intensity ultraviolet B (UVB) light dose of a very specific wavelength -- 308 nanometers -- directly at the psoriasis plaques. J Am Acad Dermatol. The use of higher fluencies was reported to result in higher occurrences of blistering. Skin Therapy Lett. Skin Therapy Lett. Wong JW, Kamangar F, Nguyen TV, Koo JY. A review of targeted ultraviolet B phototherapy for psoriasis. Over the years the excimer laser has evolved in its clinical usage, and appropriately, so have the treatment protocols that are used in clinical practice. This FDA-approved method uses a … 2002;46:900–906. Wong JW, Nguyen TV, Bhutani T, Koo JY. 2015;41(11);1201–1211. 1992;23:117–133. Within these four studies, only 26 patients with OLP were treated with the 308-nm excimer laser (Table 6,19-21). Our clinic is equipped with Alma’s Excimerlaser which is best device of worldwide. Psoriasis is a chronic, inflammatory disease that primarily manifests with cutaneous findings and affects ~3% of the American population.4 The current understanding of the pathogenesis and pathophysiology of psoriasis is continuing to evolve, but the majority of knowledge surrounds the most classical variant, psoriasis vulgaris. If you agree to our use of cookies and the contents of our Privacy Policy please click 'accept'. By the nature of the excimer laser, it is not as practical for monotherapy use in patients with severe plaque psoriasis, as the treatment field and practical application of the laser would make treatment a very time consuming and difficult process. The opinions expressed in all articles published here are those of the specific author(s), and do not necessarily reflect the views of Dove Medical Press Ltd or any of its employees. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. As its usage as a targeted monotherapy increases, future trials should consider evaluating and modifying these parameters to determine the most optimal management of localized psoriasis. J Dermatolog Treat. Treatment for palmoplantar pustular psoriasis: systematic literature review, evidence-based recommendations and expert opinion. Kagen M, Cao LY, Oyetakin-White P, Tacastacas JD, Yan C, McCormick TS, Cooper KD. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. The excimer laser is superior in inducing T cell apoptosis in vitro compared with narrowband UVB, with paralleled improved clinical efficacy. Menter A, Korman N, Elmets C, et al. 2004 Apr;15(2):94-7. doi: 10.1080/09546630310021947. Tang YJ, Xu WW, Liu XM, Zhang RZ, Xu CX, Xu B, Cheng S, Liu Q. Int J Clin Exp Med. Objective: To characterize treatment parameters for 308 nm excimer laser phototherapy. The 308 nm can also be used in the treatment of mild to moderate plaque psoriasis in children. Single administration of lesion-limited high-dose (TURBO) UVB using the excimer laser: clinical clearing in association with apoptosis of epidermal and dermal T cell subsets in psoriasis. Am J Ophthalmol. Comparison of the efficacy and safety of the 308 nm excimer laser for the treatment of localized psoriasis in adults and in children: a pilot study. COVID-19 is an emerging, rapidly evolving situation. Gordon KB, Ruderman EM. Single blinded left-to-right comparison study of excimer laser versus pulsed dye laser for the treatment of nail psoriasis. Excimer laser therapy for hairline psoriasis: a useful addition to the scalp psoriasis treatment algorithm. Ardeleanu V, Sabina Radaschin D, Tatu AL. Treatment of psoriasis and long-term maintenance using 308 nm excimer laser, clobetasol spray, and calcitriol ointment: a case series. The excimer laser has been demonstrated to be an effective treatment option for psoriasis variants and locations that may be more difficult to treat with topical modalities.32, The scalp is involved in up to 80% of patients with psoriasis, and the excimer laser can be useful in the treatment of scalp psoriasis. Photodermatol Photoimmunol Photomed. Excimer laser is currently indicated for adult and pediatric patients with mild, moderate, or severe psoriasis with <10% body surface area involvement and the American Academy of Dermatology states the level of evidence is II and the strength of recommendation is B. Frentzen M, Koort HJ, Thiensiri I. Excimer lasers in dentistry: future possibilities with advanced technology. A 308-nm excimer laser for the treatment of scalp psoriasis. Methods: J Am Acad Dermatol. Compared to the MED protocol, the induration method allows for clinicians to modify the dose as plaques begin to change in response to treatment. If someone has only a few isolated patches of psoriasis, excimer laser therapy can target their UVB treatment. UK VAT Group: GB 365 4626 36. 8 They demonstrated that the cumulative dose for complete clearance was 6.47 times less with the excimer laser than with traditional NB-UVB and that the number of treatments … J Am Acad Dermatol. 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Innovation for Breakthrough that Enabled LASIK surgery the optimal patient candidate and the treatment.
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